Table 3 Comparison of chronic comorbidities among anal fissure cases versus age- and sex-matched controls (1 to 3 matching)

No. of patients* (% of cohort)

1062

3186

Elixhauser comorbidities:

AIDS

5

0.5%

7

0.2%

0.182

Alcohol abuse

24

2.3%

97

3.0%

0.183

Chronic blood loss anemia

12

1.1%

38

1.2%

0.870

Coagulopathy

14

1.3%

43

1.4%

0.939

Congestive heart failure

27

2.5%

93

2.9%

0.521

Constipation

149

14.0%

114

3.6%

<0.001

Deficiency anemias

87

8.2%

227

7.1%

0.250

Depression

149

14.0%

387

12.2%

0.110

Diabetes (no chr complication)

147

13.8%

402

12.6%

0.303

Diabetes (w/chr complications)

30

2.8%

117

3.7%

0.191

Drug abuse

29

2.7%

112

3.5%

0.216

Fluid and electrolyte disorders

56

5.3%

168

5.3%

1.000

Hypertension

344

32.4%

959

30.1%

0.161

Hypothyroidism

156

14.7%

330

10.4%

<0.001

Liver disease

34

3.2%

84

2.6%

0.332

Lymphoma

8

0.8%

17

0.5%

0.418

Metastatic cancer

12

1.1%

23

0.7%

0.203

Obesity

138

13.0%

246

7.7%

<0.001

Other neurological disorders

48

4.5%

161

5.1%

0.486

Paralysis

7

0.7%

24

0.8%

0.755

Peripheral vascular disease

37

3.5%

109

3.4%

0.923

Pregnancy

72

6.8%

276

8.7%

0.053

Psychoses

99

9.3%

256

8.0%

0.189

Pulmonary circulation disease

23

2.2%

60

1.9%

0.565

Renal failure

29

2.7%

84

2.6%

0.869

Rheumatoid arth./ col. vasc. dz

37

3.5%

120

3.8%

0.673

Solid tumor - no metastasis

55

5.2%

118

3.7%

0.035

Valvular disease

30

2.8%

111

3.5%

0.299

Weight loss

40

3.8%

54

1.7%

<0.001

Any Elixhauser diagnosis

741

69.8%

2091

65.6%

0.013