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Table 1 Percentages of time with gastric pH above 3 and 4, and gastric acid concentrations for the 24-hour, diurnal and nocturnal periods following a single dose of placebo, 20 mg omeprazole (O) or 20 mg rabeprazole (R) in 18 obese volunteers

From: Controlling on-demand gastric acidity in obese subjects: a randomized, controlled trial comparing a single dose of 20 mg rabeprazole and 20 mg omeprazole

  Rabeprazole Omeprazole Placebo p R vs. O
% time above pH3
• 24-hour period 46.5 (37.3-54.9) 29.7 (15.2-55.5) 8.8 (4.8-10.8) 0.10
• Diurnal period 52.1 (36.4-67.8) 32.3 (14.9-64.0) 10.2 (6.2-15.1) 0.08
• Nocturnal period 38.2 (24.2-56.6) 29.5 (6.7-49.2) 4.1 (1.9-13.2) 0.25
% time above pH4
• 24-hour period 33.4 (27.2-44.3) 21.3 (10 .1-38.9) 5.3 (2.5-8.2) 0.24
• Diurnal period 37.9 (25.1-49.7) 20.1 (9.8-48.6) 4.6 (1.8-8.5) 0.21
• Nocturnal period 27.7 (14.0-49.3) 20.1 (3.3-37.4) 3.1 (0.2-10.6) 0.46
Acid concentration [H + ] mmol/l
• 24-hour period 22 (14–53) 54 (19–130) 95 (73–170) 0.01
• Diurnal period 27 (9–57) 53 (10–81) 97 (64–150) 0.05
• Nocturnal period 29 (18–48) 57 (23–160) 115(76–180) 0.01
  1. Values are medians and Interquartiles (Q1-Q3).