Table 4 Histopathological effects after sub-chronic oral ingestion (Test group, n = 7)
Organism Code | Histopathological effects (Number of affected animals/Degree of damage) | ||||
|---|---|---|---|---|---|
Liver | Kidney | Spleen | Intestine | Stomach | |
Control | No observable histopathological changes | No observable histopathological changes | No observable histopathological changes | No observable histopathological changes | No observable histopathological changes |
A246A | Essentially unremarkable normal cells (2/-) Infiltration by parenchyma cells (5/+) | Essentially unremarkable normal cells (2/-) Infiltration of tubule interstitial (5/+) | Destruction of the normal architecture (7/+) | Essentially unremarkable normal cells (1/-) Infiltration by inflammatory cells (6/+) | Essentially unremarkable normal cells (2/-) Coagulative necrosis (5/+) |
A80A | Infiltration of portal tract by chronic inflammatory cells and congestion of blood vessel (7/+) | Inflammation (3/+) Infiltration of tubule interstitial (4/++) | Stroma fibrosis with dilatation of cyanocil (7/+++) | Essentially unremarkable normal cells (1/-) Coagulative necrosis of the gland (6/++) | Tubular necrosis (3/++) Acute necrotizing inflammation (4/+) |
A245A | Aggregation (1/+) Congestion (3/++) Multinucleated hepatocytes (3/++) | Essentially unremarkable normal cells (1/+) Necrosis (4/++) Infiltration of tubule interstitial (2/++) | Coagulative necrosis (2/++) Destruction of the architecture (5/+++) | Coagulative necrosis (3/+) Coagulative necrosis with reactive glandula dysplacia (4/++) | Tubular necrosis (1/++) Coagulative necrosis (6/++) |