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Table 4 Histopathological effects after sub-chronic oral ingestion (Test group, n = 7)

From: The pathogenicity of Staphylococcus epidermidis on the intestinal organs of rats and mice: an experimental investigation

Organism Code Histopathological effects (Number of affected animals/Degree of damage)
Liver Kidney Spleen Intestine Stomach
Control No observable histopathological changes No observable histopathological changes No observable histopathological changes No observable histopathological changes No observable histopathological changes
A246A Essentially unremarkable normal cells (2/-) Infiltration by parenchyma cells (5/+) Essentially unremarkable normal cells (2/-) Infiltration of tubule interstitial (5/+) Destruction of the normal architecture (7/+) Essentially unremarkable normal cells (1/-) Infiltration by inflammatory cells (6/+) Essentially unremarkable normal cells (2/-) Coagulative necrosis (5/+)
A80A Infiltration of portal tract by chronic inflammatory cells and congestion of blood vessel (7/+) Inflammation (3/+) Infiltration of tubule interstitial (4/++) Stroma fibrosis with dilatation of cyanocil (7/+++) Essentially unremarkable normal cells (1/-) Coagulative necrosis of the gland (6/++) Tubular necrosis (3/++) Acute necrotizing inflammation (4/+)
A245A Aggregation (1/+) Congestion (3/++) Multinucleated hepatocytes (3/++) Essentially unremarkable normal cells (1/+) Necrosis (4/++) Infiltration of tubule interstitial (2/++) Coagulative necrosis (2/++) Destruction of the architecture (5/+++) Coagulative necrosis (3/+) Coagulative necrosis with reactive glandula dysplacia (4/++) Tubular necrosis (1/++) Coagulative necrosis (6/++)
  1. - = no observable effect, + = observable effect, ++ = clear histopatholigical damage, +++ = severe damage.