Histological appearance of the spleen. A. The control, showing no pathological changes. BC. Mice infected with A246A* showing mild destruction of the normal architecture of the spleen. D. Mice infected with A80A* with marked stroma fibrosis with dilatation of cyanocil. EF. Mice infected with A245A* showing E. area of coagulative necrosis F. marked destruction of the architecture of the spleen. *As shown in Table 1.