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Table 1 Characteristics of the studies included in the meta-analysis

From: Fecal lactoferrin in discriminating inflammatory bowel disease from Irritable bowel syndrome: a diagnostic meta-analysis

Study Year Age(mean/range) Nation Number of patients FL assay Cut off Test result SEN (95% CI) SPE (95% CI)
IBD UC CD IBS control TP FP FN TN
Walker 2007 13.4/2-21 American 141 62 79 7 22 IBD-SCAN 7.25 ug/ml 118 1 23 28 0.84 (0.77-0.89) 0.97 (0.82-1.00)
Schoepfer 2008 20-79 Switzerland 64 28 36 30 42 IBD-SCAN 7.0 ug/ml 55 1 9 29 0.86 (0.75-0.93) 0.97 (0.83-1.00)
Langhorst 2008 15-70 Germany 85 42 43 54 - IBD-SCAN 7.05 ug/ml 68 1 17 45 0.80 (0.70-0.88) 0.83 (0.71-0.92)
Kane 2003 10-78 American 149 71 78 31 56 IBD-SCAN 4 ug/g 111 0 38 31 0.74 (0.67-0.81) 1.00 (0.89-1.00)
Schroder 2007 20-75 Germany 45 20 25 31 - IBD-SCAN 7.3 ug/g 37 0 8 31 0.82 (0.68-0.92) 1.00 (0.89-1.00)
Sidhu 2010 42/58/56* UK 230 126 104 137 98 IBD-SCAN 7.25 ug/g 70§ 6 32 131 0.69 (0.59-0.77) 0.96 (0.91-0.98)
Otten 2008 52.3/44.5 Netherlands 23 - - 91 - IBD-SCAN 7.25 mg/ml 18 9 5 82 0.78 (0.56-0.93) 0.90 (0.82-0.95)
  1. *Numbers are mean values for IBS, UC and CD respectively. Numbers are mean values for IBS and IBD respectively.
  2. Include 22 healthy volunteers. §Only calculated active IBD.