Fecal lactoferrin in discriminating inflammatory bowel disease from Irritable bowel syndrome: a diagnostic meta-analysis

Table 1 Characteristics of the studies included in the meta-analysis

Study	Year	Age(mean/range)	Nation	Number of patients					FL assay	Cut off	Test result				SEN (95% CI)	SPE (95% CI)
Study	Year	Age(mean/range)	Nation	IBD	UC	CD	IBS	control	FL assay	Cut off	TP	FP	FN	TN	SEN (95% CI)	SPE (95% CI)
Walker	2007	13.4/2-21	American	141	62	79	7	22	IBD-SCAN	7.25 ug/ml	118	1	23	28^‡	0.84 (0.77-0.89)	0.97 (0.82-1.00)
Schoepfer	2008	20-79	Switzerland	64	28	36	30	42	IBD-SCAN	7.0 ug/ml	55	1	9	29	0.86 (0.75-0.93)	0.97 (0.83-1.00)
Langhorst	2008	15-70	Germany	85	42	43	54	-	IBD-SCAN	7.05 ug/ml	68	1	17	45	0.80 (0.70-0.88)	0.83 (0.71-0.92)
Kane	2003	10-78	American	149	71	78	31	56	IBD-SCAN	4 ug/g	111	0	38	31	0.74 (0.67-0.81)	1.00 (0.89-1.00)
Schroder	2007	20-75	Germany	45	20	25	31	-	IBD-SCAN	7.3 ug/g	37	0	8	31	0.82 (0.68-0.92)	1.00 (0.89-1.00)
Sidhu	2010	42/58/56*	UK	230	126	104	137	98	IBD-SCAN	7.25 ug/g	70^§	6	32	131	0.69 (0.59-0.77)	0.96 (0.91-0.98)
Otten	2008	52.3/44.5^†	Netherlands	23	-	-	91	-	IBD-SCAN	7.25 mg/ml	18	9	5	82	0.78 (0.56-0.93)	0.90 (0.82-0.95)

*Numbers are mean values for IBS, UC and CD respectively. ^†Numbers are mean values for IBS and IBD respectively.
^‡Include 22 healthy volunteers. ^§Only calculated active IBD.

ISSN: 1471-230X