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Table 2 Genotype frequencies of MRC1 and IL28B single nucleotide polymorphisms in HCV-1 infected PEG-IFNα-RBV therapy patients with and without SVR in Taiwan Chinese population

From: Association of MRC-1 and IL-28Bwith the treatment outcome of hepatitis C: a case control study

MRC1 IL28B
Genotype SVR (+) SVR (−) P OR (95% CI) Genotype SVR(+) SVR (−) P OR (95% CI)
N (%) N (%) N (%) N (%)
( MRC1 ) rs1926736 ( IL28B ) rs955155
C/C 57 (35.0) 31 (30.4)   0.97 (0.49, 1.92) C/C 155 (95.1) 86 (84.3)   1
C/T 66 (40.5) 50 (49.0)   0.69 (0.36, 1.32) C/T 7 (4.3) 16 (15.7)   0.24 (0.1-0.61)
T/T 40 (24.5) 21 (20.6) 0.39 1 T/T 1 (0.6) 0 (0.0) 0.005* -
C/C + C/T 123 (75.5) 81 (79.4) 0.46 0.80 (0.44, 1.45) T/T + C/T 8 (4.9) 16 (15.7) 0.003* 0.28 (0.11-0.67)
( MRC1 ) rs691005 ( IL28B ) rs8099917
C/C 13 (8.0) 12 (11.8)   1.16 (0.49, 2.75) T/T 151 (92.6) 74 (72.5)   1
C/T 93 (57.1) 29 (28.4)   3.43 (1.98, 5.96) T/G 11 (6.7) 28 (27.5)   0.19 (0.09-0.41)
T/T 57 (34.9) 61 (59.8) <0.0001* 1 G/G 1 (0.7) 0 (0.0) <0.0001* -
C/C + C/T 106 (65.1) 41 (40.2) <0.0001* 2.77 (1.66, 4.61) G/G + T/G 12 (7.4) 28 (27.5) <0.0001* 0.21 (0.1-0.44)
  ( IL28B ) rs10853728
      C/C 115 (71.0) 66 (65.3)   1
      C/G 47 (29.0) 35 (34.7) 0.34 0.77 (0.45-1.31)
      G/G 0 (0.0) 0 (0.0) - -
      G/G + C/G 47 (29.0) 35 (34.7) 0.34 0.77 (0.45-1.31)
  1. Abbreviations: SNP, single nucleotide polymorphism; SVR, sustained virological response; OR, odds ratio; CI, confidence interval.
  2. Genotype frequencies were determined by χ2 test using 3 × 2 or 2 × 2 tables as appropriate. Odds ratios and 95% CI per genotype were estimated by applying unconditional logistic regression. The P values less than 0.05 were considered significant, and are denoted with an asterisk.