Table 2 Genotype frequencies of MRC1 and IL28B single nucleotide polymorphisms in HCV-1 infected PEG-IFNα-RBV therapy patients with and without SVR in Taiwan Chinese population
From: Association of MRC-1 and IL-28Bwith the treatment outcome of hepatitis C: a case control study
MRC1 | IL28B | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Genotype | SVR (+) | SVR (−) | P | OR (95% CI) | Genotype | SVR(+) | SVR (−) | P | OR (95% CI) |
N (%) | N (%) | N (%) | N (%) | ||||||
( MRC1 ) rs1926736 | ( IL28B ) rs955155 | ||||||||
C/C | 57 (35.0) | 31 (30.4) | 0.97 (0.49, 1.92) | C/C | 155 (95.1) | 86 (84.3) | 1 | ||
C/T | 66 (40.5) | 50 (49.0) | 0.69 (0.36, 1.32) | C/T | 7 (4.3) | 16 (15.7) | 0.24 (0.1-0.61) | ||
T/T | 40 (24.5) | 21 (20.6) | 0.39 | 1 | T/T | 1 (0.6) | 0 (0.0) | 0.005* | - |
C/C + C/T | 123 (75.5) | 81 (79.4) | 0.46 | 0.80 (0.44, 1.45) | T/T + C/T | 8 (4.9) | 16 (15.7) | 0.003* | 0.28 (0.11-0.67) |
( MRC1 ) rs691005 | ( IL28B ) rs8099917 | ||||||||
C/C | 13 (8.0) | 12 (11.8) | 1.16 (0.49, 2.75) | T/T | 151 (92.6) | 74 (72.5) | 1 | ||
C/T | 93 (57.1) | 29 (28.4) | 3.43 (1.98, 5.96) | T/G | 11 (6.7) | 28 (27.5) | 0.19 (0.09-0.41) | ||
T/T | 57 (34.9) | 61 (59.8) | <0.0001* | 1 | G/G | 1 (0.7) | 0 (0.0) | <0.0001* | - |
C/C + C/T | 106 (65.1) | 41 (40.2) | <0.0001* | 2.77 (1.66, 4.61) | G/G + T/G | 12 (7.4) | 28 (27.5) | <0.0001* | 0.21 (0.1-0.44) |
( IL28B ) rs10853728 | |||||||||
C/C | 115 (71.0) | 66 (65.3) | 1 | ||||||
C/G | 47 (29.0) | 35 (34.7) | 0.34 | 0.77 (0.45-1.31) | |||||
G/G | 0 (0.0) | 0 (0.0) | - | - | |||||
G/G + C/G | 47 (29.0) | 35 (34.7) | 0.34 | 0.77 (0.45-1.31) | |||||