Effect of NOD2 variants on PCDAI and CDAI Score in pediatric- and adult-onset CD patients. CD patients with pediatric-onset (A) and adult-onset (B) are compared regarding NOD2 variant (grey bars) or NOD2 wild-type alleles (white bars) and their average PCDAI or CDAI Score. The median (lines within the boxes), the interquartile range (boxes) and the whole range are given. Differences were compared using unpaired, two sided Mann–Whitney test. A p-value below ≤0.05 was considered to be significant.