Effect of NOD2 gene variants in CD patients on disease behaviour. CD patients with pediatric-onset (A) or adult-onset (B) of disease with NOD2 variant (grey bars) or NOD2 wild-type alleles (white bars) are compared regarding family history (FA) of IBD, extraintestinal manifestation (EIM), surgery or complication because of CD, and osteoporosis. BMD was available from 169 out of 202 patients. Differences were compared using chi-square or Fishers exact test, respectively. A p-value below ≤0.05 was considered to be significant.