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Table 2 Results of overall meta-analysis

From: Meta-analysis: preoperative transcatheter arterial chemoembolization does not improve prognosis of patients with resectable hepatocellular carcinoma

Outcomes No. of studies No.of patients Results OR (95% CI) P value HG p value
TACE (+) TACE (−) TACE (+) TACE (−)
Long-term outcomes         
5-years disease-free survival 18[10, 11, 1316, 24, 28, 3140] 1275 1567 32.1% 30.0% 1.19 (0.93, 1.53) 0.17 0.02
5-years overall survival 16[11, 12, 1416, 24, 28, 29, 31, 3440] 1038 1463 40.2% 45.2% 0.85 (0.59, 1.22) 0.37 <0.01
Total recurrence 11[10, 14, 16, 24, 30, 32, 35, 36],[3840] 673 917 61.0% 58.4% 0.99 (0.72, 1.36) 0.95 0.08
Intrahepatic recurrence 12[1012, 14, 16, 24, 29, 30, 32, 35],[36, 39] 660 797 51.2% 53.6% 0.84 (0.67, 1.05) 0.12 0.23
Extrahepatic recurrence 9[10, 14, 16, 24, 30, 32, 35, 36],[39] 519 591 12.9% 10.3% 1.30 (0.88, 1.92) 0.19 0.33
Short-term outcomes         
Overall morbidity 11[1012, 14, 16, 24, 29, 30, 35, 36],[40] 583 803 28.9% 26.8% 1.02 (0.80, 1.32) 0.85 0.42
Liver failure 6[11, 12, 14, 16, 29, 36] 337 457 5.9% 6.3% 1.06 (0.57, 1.96) 0.86 0.31
Bile leakage 6[12, 14, 16, 29, 35, 36] 371 569 3.5% 2.8% 1.12 (0.53, 2.35) 0.77 0.80
Pleural effusion 4[12, 29, 35, 36] 300 485 7.0% 8.0% 0.93 (0.53, 1.65) 0.24 0.26
Ascites 3[29, 35, 36] 269 378 6.3% 6.1% 0.98 (0.51, 1.89) 0.96 0.16
Intra-abdominal abscess 5[11, 14, 29, 35, 36] 348 451 2.5% 1.3% 1.66 (0.63, 4.40) 0.31 0.58
Wound infection 5[12, 14, 16, 35, 36] 311 501 3.2% 2.5% 1.11 (0.48, 2.53) 0.81 0.35
Postoperative bleeding 3[11, 12, 36] 206 305 3.3% 2.9% 1.25 (0.41, 3.81) 0.69 0.63
Stress ulcer bleeding 3[12, 29, 35] 180 332 1.1% 1.2% 1.31 (0.29, 5.92) 0.73 0.74
Pneumonia 4[11, 12, 14, 35] 199 337 4.0% 2.1% 1.64 (0.60, 4.46) 0.33 0.23
Mortality 16[1012, 1416, 24, 2830, 3336, 38, 40] 1100 1325 4.1% 3.1% 1.25 (0.80, 1.97) 0.33 0.85
  1. HG heterogeneity.