Table 3 Results of Cox multivariate analysis in the entire patients’ cohort ¹

Clinical-pathological features

Age

1.93

(0.2)

1.71

(0.3)

Sex

0.70

(0.5)

0.81

(0.7)

Tumour location

1.50

(0.4)

1.85

(0.2)

Tumour grade

1.29

(0.7)

0.81

(0.7)

5-FU treatment

1.23

(0.7)

1.12

(0.8)

Depth of tumour invasion

0.94

(0.9)

1.27

(0.7)

Lymphovascular invasion

0.70

(0.4)

0.61

(0.3)

Large veins invasion

1.08

(0.9)

0.88

(0.8)

Tumour inflammatory response

0.39

(0.06)

0.40

(0.09)

Tumour border configuration

2.77

( 0.06 )

2.91

(0.1)

Molecular parameters

MMR system

1.54

(0.6)

0.97

(1.0)

CIMP

0.58

(0.2)

0.60

(0.3)

TS by mRNA

1.15

(0.7)

1.31

(0.5)

TS by IHC

0.88

(0.8)

0.64

(0.4)

TP53

0.62

(0.2)

0.37

(0.08)

CTNNB1activation grades

0.80

(0.4)

0.90

(0.8)

BRAF c.1799 T > A

2.57

(0.04)

3.68

(<0.01)