Table 4 Comparison of EGF genotype frequencies in HCC patients with control subjects among non-Asians in Los Angeles, California, and Chinese in southern Guangxi, China, stratified by cytokine genotypes
Th1 and Th2 genotypes* | EGF 61A > G | Non-Asians in Los Angeles | Chinese in southern Guangxi | ||||
|---|---|---|---|---|---|---|---|
Ca/Co* | OR (95% CI)† | OR (95% CI)‡ | Ca/Co* | OR (95% CI)† | OR (95% CI)‡ | ||
No. of low-activity Th1 genotypes | |||||||
0–1 | A/A | 13/27 | 1.00 (ref) | 1.00 (ref) | 70/76 | 1.00 (ref) | 1.00 (ref) |
A/G + G/G | 38/86 | 1.14 (0.50–2.63) | 1.24 (0.46–3.34) | 61/77 | 0.87 (0.54–1.39) | 0.63 (0.32–1.23) | |
2–3 | A/A | 11/25 | 1.00 (ref) | 1.00 (ref) | 55/42 | 1.00 (ref) | 1.00 (ref) |
A/G + G/G | 50/60 | 2.17 (0.91–5.18) | 2.77 (1.00–7.66) | 63/50 | 0.95 (0.55–1.65) | 0.89 (0.40v1.97) | |
No. of low-activity Th2 genotypes | |||||||
0 | A/A | 7/13 | 1.00 (ref) | 1.00 (ref) | 72/61 | 1.00 (ref) | 1.00 (ref) |
A/G + G/G | 18/28 | 1.85 (0.48–7.15) | 1.36 (0.23–8.27) | 55/48 | 0.97 (0.58–1.63) | 0.78 (0.36–1.69) | |
1–2 | A/A | 17/39 | 1.00 (ref) | 1.00 (ref) | 53/57 | 1.00 (ref) | 1.00 (ref) |
A/G + G/G | 70/118 | 1.63 (0.83–3.20) | 2.27 (1.01–5.11) | 69/79 | 0.95 (0.58–1.56) | 0.84 (0.42–1.71) | |
No. of low-activity Th1 and Th2 genotypes | |||||||
Th1 = 0–1 and Th2 = 1–2 | A/A | 13/19 | 1.00 (ref) | 1.00 (ref) | 35/31 | 1.00 (ref) | 1.00 (ref) |
A/G + G/G | 33/70 | 0.86 (0.36–2.04) | 0.95 (0.33–2.70) | 36/48 | 0.69 (0.36–1.33) | 0.57 (0.21–1.54) | |
Th1 = 2–3 or Th2 = 0 | A/A | 11/33 | 1.00 (ref) | 1.00 (ref) | 90/87 | 1.00 (ref) | 1.00 (ref) |
A/G + G/G | 55/76 | 2.75 (1.18–6.38) | 3.34 (1.24–9.03) | 88/79 | 1.07 (0.70–1.63) | 0.85 (0.47–1.56) | |