Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease

BMC Gastroenterology

Table 4 The frequency of the polymorphism D19H in the gallstone carriers and controls of the population from Stuttgart

Group	Controls (134)			Gallstone carriers (34)			(GG<>Gc)
Genotype	G/G	G/c	c/c	G/G	G/c	c/c	P-value	OR (95% CI)
Total	115	19	0	23	11	0	0.022	2.9(CI: 1.216 to 6.889)
Normal weight	66	9	0	9	2	0	0.627	1.6(CI: 0.303 to 8.770)
Overweight	49	10	0	14	9	0	0.043	3.2(CI: 1.071 to 9.264)

G = major allele, c = minor allele, OR = odds ratio, CI = confidence interval.
Statistical analysis of genotype frequency differences between gallstone carriers and controls was done using Fisher’s exact test. Odds ratios (ORs) together with a 95% confidence interval (CI) are given as risk measures for the development of gallstones. All statistical tests were two-tailed and a P-value of <0.05 was considered as statistically significant.

ISSN: 1471-230X