Figure 3
Effect of ozagrel on plasma 2,3-dinor TXB 2 levels in APAP-induced liver injury. Mice were treated with ozagrel (200 mg/kg) or saline 30 min after the APAP (330 mg/kg) injection. Plasma 2,3-dinor TXB2 levels were measured by enzyme immunoassay 4 h after the APAP injection. There was a significant increase in plasma 2,3-dinor TXB2 in the APAP group (black bar) compared with the vehicle group (white bar). The increase was significantly suppressed by ozagrel (the APAP + ozagrel group; gray bar). Each value represents the mean ± S.E.M. (n = 6). **p < 0.01.