The Role of Fbxw7 in the Inversed Expression Pattern between CD44v and c-Myc Go Yoshida, School of Medicine, Keio University 4 August 2014 CD44 variant isoform (CD44v) is widely recognized to be a functional cancer stem cell marker to reduce reactive oxygen species. The inversed pattern was firstly identified in the normal gastric mucosa as well as tumor xenograft model. CD44v8-10(+) cells do not easily activate canonical Wnt signaling pathway as CD44v8-10(-) cells, which is why GRHL2-ESRP1-CD44v-xCT-GSH (glutathione) axis is regarded to be critical to repress the up-regulation of proto-oncogenic molecules such as c-Myc. Tumor tissue at the invasive area is considered to be composed of heterogeneous cellular population; dormant cancer stem-like cells with CD44v8-10 high/ Fbw7 high/ c-Myc low and proliferative cancer stem-like cells with CD44v8-10 high/ Fbw7 low/ c-Myc high. Ref Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation (Biochem Biophys Res Commun. 2014 Jan10;443(2):622-7.). Competing interests No Competing Interests Exist.