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Table 2 Methodology quality of the included studies

From: The role of Ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review

Study Randomization Double blinding Withdrawn Total score
Monotherapy
Laurin et al. [24] Inadequate (no description) No 5 vs. 5 2
Lindor et al. [25] Inadequate (no description) Yes 6 vs. 2 4
Dufour et al. [20] Adequate (randomization list set up by pharmacy before study) Yes 3 vs. 2 4
Kiyici et al. [26] Inadequate (no description) No NM 2
Hong Qian, et al. [32] Adequate (1:1 ratio) NM 0 vs. 0 3
Zhu Hong-Juan [27] Inadequate (no description) No 0 vs. 0 2
Ratziu et al. [28] Adequate (1:1 ratio in blocks of four) Yes 7 vs. 3 5
Leuschner et al. [29] Inadequate (no description) Yes 39 in total 4
UDCA combined with other drugs
Dufour et al. [20] Adequate Yes 3 vs. 2 4
Zhuang Xue-shan [30] Inadequate (no description) NM 0 vs. 0 2
Sun Yan [31] Inadequate (no description) NM NM 2
Lv Hong [33] Inadequate (no description) NM NM 2
Liu Zhi-ye [34] Inadequate (no description) NM NM 2
  1. All comparisons were treatment vs. control; NM not mentioned.