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Table 3 Ferritin with cut-off values of 100 mcg/L and 50 mcg/L, and anaemia in the diagnosis of gastrointestinal cancers (in paranthesis are 95% CI)

From: Ferritin above 100 mcg/L could rule out colon cancer, but not gastric or rectal cancer in patients with involuntary weight loss

   Gastrointestinal cancer Colorectal cancer
Ferritin (cut-off 100 mcg/L) Sensitivity (%) 86 (67–95) 93 (69–100)
  Specificity (%) 57 (51–62) 56 (50–62)
  Positive predictive value (%) 14 (9–21) 10 (6–16)
  Negative predictive value (%) 98 (94–100) 99 (96–100)
  Positive likelihood ratio 2 2.1
  Negative likelihood ratio 0.24 0.13
  Sensitivity (%) 59 (39–77) 64 (39–84)
  Specificity (%) 76 (71–81) 75 (70–80)
Ferritin (cut-off 50 mcg/L) Positive predictive value (%) 17 (10–27) 12(6–20)
  Negative predictive value (%) 96 (92–98) 98 (95–99)
  Positive likelihood ratio 2.5 2.6
  Negative likelihood ratio 0.54 0.47
  Sensitivity (%) 68 (47–84) 64 (39–84)
  Specificity (%) 51 (45–57) 50 (44–56)
Anaemia Positive predictive value (%) 10 (6–16) 6 (3–11)
  Negative predictive value (%) 95 (90–98) 97 (92–99)
  Positive likelihood ratio 1.4 1.3
  Negative likelihood ratio 0.63 0.71