A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population

Table 2 Genotyping results for ABCB11 c.1331 T > C from patients and controls

*ABCB11*p.V444A (c.1331 T > C) alleles/genotypes	Counts (frequencies) of alleles/genotypes
	Cases (N = 649)	Controls (N = 413)
[T]	511 (0.39)	359 (0.43)
[C]	787 (0.61)	467 (0.57)
[TT]	97 (0.15)	82 (0.20)
[TC]	317 (0.49)	195 (0.47)
[CC]	235 (0.36)	136 (0.33)
Tests for association	chi ²	P
Allele frequency difference	3.50	0.061
Armitage’s trend test	3.49	0.062
OR statistics	OR (95% CI)	P
[C] ↔ [T]	1.18 (0.99 - 1.41)	0.061
[CC] ↔ [TT]	1.46 (1.02 - 2.10)	0.040
[CC + CT] ↔ [TT]	1.41 (1.02 - 1.95)	0.037

Patients with HCV infections are regarded as cases.
Abbreviations: A, alanine; ABCB11, ATP-binding cassette, subfamily B, member 11; CI, confidence interval; OR, odds ratio; p, protein (amino acid number), V, valine.

ISSN: 1471-230X