Figure 2

sIL-2R levels of are associated with circulating monocyte subpopulations. (A) CD25 expression was studied by FACS on circulating monocyte subsets. A representative histogram displays that CD14⁺CD16⁺ monocytes express higher levels of CD25 than the classical CD14⁺⁺ monocytes. (B) FACS plots from two representative patients display an increase of CD14⁺CD16⁺ monocytes (right gate) among freshly isolated PBMC. The left plot is derived from a patient with Child A cirrhosis (corresponding sIL-2R 520 kU/L) and the right plot from patient with Child C cirrhosis (sIL-2R 1203 kU/L). (C) Serum levels of sIL-2R correlate with numbers of total circulating monocytes (left plot), classical CD14⁺⁺ monocytes (middle plot) and CD14⁺CD16⁺ monocytes (right plot, Spearman rank correlation test).