Figure 3

A. Proximal intestinal myeloperoxidase (MPO) assay from Swiss mice challenged by 5-FU-induced intestinal mucositis (450 mg/kg via i.p., single dose) and treated with the apoE mimetic peptide COG 133 (0.3, 1, and 3 μM, via i.p., 12/12 h, vol. 10 μl/g) or 0.9% saline (i.p.). B, C, and D. IL-1β, TNF-α, and IL-10 Elisa assays, respectively, from Swiss mice challenged by 5-FU-induced intestinal mucositis (450 mg/kg via i.p., single dose) and treated with the apoE mimetic peptide COG 133 (0.3, 1 and 3 μM, via i.p., 12/12 h, vol. 10 μl/g) or 0.9% saline (i.p.). Proximal intestine segments were harvested from experimental mice on the fourth day. Values represent mean ± SEM and were analyzed by one-way ANOVA. At least four animals were used per group. At least N = 7 for all groups.