The Zelnorm epidemiologic study (ZEST): a cohort study evaluating incidence of abdominal and pelvic surgery related to tegaserod treatment

Table 5 Incidence rates and relative risks of gallbladder surgery (as-treated analysis)

Variable	Events	Person years	Incidence rate¹	95% Confidence interval		Rate ratio¹	95% Confidence interval
				Low	High		Low	High
Tegaserod Use
Current	17	545	0.03	0.02	0.05	0.99	0.56	1.77
Recent	10	179	0.06	0.03	0.10	1.78	0.88	3.59
Past	10	401	0.02	0.01	0.05	0.85	0.42	1.72
Non-Use	36	1,115	0.03	0.02	0.04	1.00
Gender
Female	67	1,999	0.03	0.03	0.04	1.00
Male	6	242	0.02	0.01	0.05	0.68	0.29	1.57
Age
0 - 29	9	293	0.03	0.01	0.06	1.00
30 - 49	44	1,135	0.04	0.03	0.05	1.35	0.66	2.77
50 +	20	813	0.02	0.02	0.04	0.87	0.39	1.91
Gallbladder Surgery Risk Factors
Cholelithiasis (574)	14	44	0.32	0.18	0.54	8.51	4.23	17.14
Gallbladder or Bile Duct Surgeries	3	30	0.10	0.02	0.29	0.20	0.06	0.73
Constipation (564.0)	17	814	0.02	0.01	0.03	0.56	0.32	0.96
Diagnostic Procedures²	35	295	0.12	0.08	0.17	4.44	2.67	7.39

¹ Adjusted for gender, age, cholelithiasis, gallbladder surgery, constipation, and diagnostic procedures.
² Composite variable consisting of abdominal ultrasound and radiographic visualization of the gallbladder.

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