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Table 1 Characteristics of the different groups in the spectrum of coeliac disease

From: Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study

 

SPECTRUM OF CD

 

ACD

GFD

RCDI

RCDII

EATL

 

(n = 26)

(n = 26)

(n = 12)

(n = 16)

(n = 12)

Age at CD (yr)

Median, (SD;range)

42.5

45

50.5

61.5

61.5

(16; 21-76)

( 15; 21-77)

(16; 19-69)

(13; 27-74)

(7; 48-66)

Age at RCD

Median, (SD;range)

-

-

59

65

64

(11.5; 35-74)

(10; 47-77)

(8; 51-72)

Age at EATL

Median, (SD;range)

-

-

-

-

65

(6; 51-74)

HLA-staus

DQ2 heterozygous

10

7

8

7

3

DQ8 heterozygous

9

13

  

3

DQ2/8 heterozygous

3

2

1

3

2

DQ2 homozygous

4

4

3

6

4

Marsh

0

 

12

  

2

I

 

4

   

II

    

1

IIIA

11

 

8

9

5

IIIB

5

 

3

4

3

IIIC

10

 

1

3

1

ND

 

10

   

EMA

Negative (-)

 

26

12

15

7

Dubious (+/-)

   

1

2

Weak positive (+)

3

    

Positive (++)

11

   

0

Stronglypositive(+++)

11

   

2

ND

1

   

1

TGA

Negative

 

7

12

14

6

Dubious

   

2

2

Weak positive

8

   

1

Positive

6

   

1

Strongly positive

9

   

1

ND

3

19

  

1

Aberrant IELs (%)

Mean (SD;range)

-

-

4,0

64

7

(6.0; 2-19)

(23; 20-96)

(32; 1-87)

EATL type

Primary

-

-

-

-

4

 

Secondary

    

8

  1. ACD: active coeliac disease patients; GFD: coeliac disease patients on a gluten-free diet; RCDI and II: refractory coeliac disease type I and II; EATL: enteropathy associated T-cell lymphoma; EMA-A: endomysial antibodies; tTGA-A: tissue transglutaminase antibodies; IELs: intra-epithelial lymphocytes.
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BMC Gastroenterology

ISSN: 1471-230X

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