Pantoprazole induced the expression of HO-1. (A) RT-PCR and Western blot for HO-1 expression according to different dosing of pantoprazole, 30, 100, and 300 μM, respectively. These figures are representatives of the results obtained in 3 independent experiments. (B) Confocal imaging of HO-1. Pantoprazole increased the expression of HO-1 in a dose-dependent manner in normal rat gastric mucosal RGM-1 cells.