Table 5 Variables associated with and independent predictors of low adiponectin levels (<6 mg/ml) in 144 NAFLD patients and 257 healthy controls with very low probability of steatosis
Adiponectin | Low (n = 217) | High (n = 194) | p | OR * (95% c.i.) | p * |
|---|---|---|---|---|---|
NAFLD present | 89 (46) | 52 (24) | 0.002 | 1.65 (1.02-2.70) | 0.043 |
Age (years) | 46±11 | 51±13 | 0.007 | 0.96 (0.94-0.98) | <0.0001 |
Sex (F) | 20 (9) | 67 (34) | <0.0001 | 0.21 (0.11-0.37) | <0.0001 |
BMI (Kg/m2) | 26.2±3.0 | 25.0±3.1 | <0.0001 | 1.15 (1.07-1.25) | 0.0002 |
HDL (mg/dl) | 48±12 | 57±14 | <0.0001 | - | - |
Triglycerides (mg/dl) | 119±68 | 92±47 | <0.0001 | - | - |
ALT (IU/ml) | 42±38 | 29±25 | <0.0001 | - | - |
Insulin (IU/ml) | 17±14 | 13±8 | 0.003 | - | - |
FFAs (mmol/l) | 0.21±0.09 | 0.19±0.08 | 0.05 | - | - |
ADIPOQ | |||||
rs2241766TT and rs1501299T+ | 83 (38) | 100 (52) | 0.008 | 0.61 (0.39-0.95) | 0.030 |
rs2241766G + or rs1501299GG | 134 (62) | 94 (48) | reference | ||
PNPLA3 rs738409 | |||||
CC (148 I/I) | 97 (45) | 112 (58) | 0.01 | 1.67° (1.07-2.64) | 0.024 |
CG (148 I/M) | 94 (43) | 71 (37) | |||
GG (148 M/M) | 26 (12) | 11 (6) |