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Table 2 Antibody distribution in 169 patients with Crohn’s disease (CD), 102 patients with ulcerative colitis (UC), and 225 controls

From: Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn’s disease

 

CD

UC

controls

 

All CD patients (n = 169)

ASCA negative CD patients (n = 109)

(n = 102)

(n = 225)

Anti-GP2 IgA, (%)

22 (13.0)

9 (8.2)

2 (2.0)

3 (1.3)

Anti-GP2 IgG, (%)

48 (28.4)

25 (22.9)

8 (7.8)

6 (2.7)

Anti-GP2 IgA and/or IgG, (%)

51 (30.2)

26 (23.9)

9 (8.8)

9 (4.0)

PAB > = 1/20, (%)

74 (43.8)

45 (41.3)

24 (23.5)

nd

PAB > = 1/40, (%)

65 (38.5)

38 (34.9)

21 (20.6)

nd

ASCA IgA, (%)

39 (23.1)

-

3 (2.9)

2 (0.9)

ASCA IgG, (%)

48 (28.4)

-

5 (4.9)

7 (3.1)

ASCA IgA and/or IgG, (%)

60 (35.5)

-

7 (6.9)

8 (3.5)

ASCA and/or anti-GP2, (%)

86 (50.9)

-

15 (14.7)

16 (7.1)

Number of positive antibodies detected by ELISA

    

0

83 (49.1)

83 (76.1)

87 (85.3)

208 (92.4)

1

40 (23.7)

18 (16.5)

12 (11.8)

13 (5.8)

2

28 (16.6)

8 (7.3)

3 (2.9)

4 (1.8)

3

11 (6.5)

-

0 (0.0)

0 (0.0)

4

7 (4.1)

-

0 (0.0)

0 (0.0)

  1. ASCA, antibody to mannan of Saccharomyces cerevisiae; CI, confidence interval; GP2, zymogen granule membrane glycoprotein 2; nd, not done; PAB, pancreatic autoantibody.