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Table 4 Risk genotypes related to BCH, ESCD and ESCC in the multinomial logistic regression models a

From: Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County

Factors BCH
OR(95%CI)
ESCD
OR(95%CI)
ESCC
OR(95%CI)
ORG(95%CI) #
MTHFR C677T     
TT 0.91(0.59-1.40) 0.78(0.48-1.28) 1.85(1.02-3.34) 1.16(1.00-1.35)
CT 0.89(0.58-1.37) 0.56(0.34-1.03) 1.72(0.95-3.10)  
TT&TC 0.90(0.62-1.32) 0.66(0.43-1.12) 1.71(1.01-2.91)  
CC 1.00 1.00 1.00  
MPO G463A     
GG 1.09(0.64-1.86) 2.13(0.90-5.08) 0.96(0.52-1.78) 0.93(0.72-1.19)
GA&AA 1.00 1.00 1.00  
CYP2E1 G1259C     
C2/C2 & C1/C2 1.15(0.64-2.09) 0.79(0.38-1.62) 1,01(0.43-2.33) 0.94(0.77-1.14)
C1/C1 1.00 1.00 1.00  
hOGG1 C326G     
GG 1.56(0.71-3.43) 1.23(0.46-3.26) 0.50(0.14-1.81) 1.00(0.85-1.78)
GC 1.10(0.66-1.86) 2.33(1.24-4.36) 1.45(0.72-2.92)  
GG&GC 1.2990.73-1.97) 2.08(1.14-3.76) 1.23(0.63-2.40)  
CC 1.00 1.00 1.00  
ALDH2     
2*2 4.15(2.33-7.40) 4.54(2.32-8.89) 3.38(1.64-6.95) 1.52(1.30-1.77)
1*2 1.19(0.72-1.95) 0.65(0.34-1.22) 1.39(0.73-2.64)  
2*2&1*2 1.73(1.07-2.81) 1.43(0.79-2.58) 1.80(0.97-3.38)  
1*1 1.00 1.00 1.00  
  1. a: Adjusted for age, sex, income, school year, smoking, drinking and family history of esophageal cancer. Abbreviations: BCH, Basal cell hyperplasia; ESCD, esophageal squamous cell dysplasia; ESCC, Esophageal Squamous cell cancer; ORG: generalized odds ratio.
  2. #: ORG: calculated by the software "ORGGASMA" of the web site htpp://biomath.med.uth.gr.(note:: added 0.5 to zero frequency of cell).