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Table 1 Overview of results: Symptoms association with cancer.

From: Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review

Symptom DOR* (95% CI*) AUC** Sensitivity (95% CI) 1-specificity
(95% CI)
LR+ (95% CI) LR- (95% CI)
Rectal bleeding# 2.6
(1.9-3.6)
p < 0.001
0.66 0.46
(0.38-0.55)
0.25
(0.19-0.31).
1.9
(1.5-2.3)
0.7
(0.6-0.8)
Blood mixed with stool: 3.1
(2.0-4.8)
p < 0.001
0.68 0.49
(0.30-0.69)
0.24
(0.13-0.40)
2.1
(1.5-2.8)
0.7
(0.5-0.9)
Blood: dark red 3.9
(1.7 - 9.2)
P = 0.004
0.71 0.29
(0.09-0.65)
0.10
(0.03-0.28)
3.1
(1.6-6.0)
0.8
(0.6-1.1)
Change in bowel habit 1.5
(0.8-2.8)
p = 0.16
0.57 0.32
(0.21-0.46)
0.24
(0.15-0.35)
1.4
(0.9-2.1)
0.9
(0.7-1.1)
Constipation 1.1
(0.8-1.5)
p = 0.48
0.52 0.12
(0.08-0.18)
0.11
(0.07-0.16).
1.1
(0.8-1.5)
1.0
(1.0-1.0)
Diarrhoea 0.9
(0.4-1.7)
p = 0.65
0.47 0.15
(0.07-0.28)
0.17
(0.09-0.29)
0.9
(0.5-1.6)
1.0
(0.9-1.1)
Abdominal pain 0.7
(0.5-1.1)
p = 0.12
0.45 0.19
(0.13-0.28)
0.24
(0.17-0.33).
0.8
(0.6-1.1)
1.1
(1.0-1.2)
Weight loss 2.9
(1.6-5.0)
p = 0.001
0.67 0.20
(0.12-0.31)
0.08
(0.05-0.13).
2.5
(1.5-4.0)
0.9
(0.8-1.0)
  1. *DOR = diagnostic odds ratio. No association between symptom and cancer if DOR = 1
  2. **AUC = area under the Receiver operating characteristic curve. No association between symptom and cancer if AUC = 0.5
  3. # Bleeding of any type
  4. Note: Results for bleeding types for which there 3 or more papers or for which the DOR was > 1 are shown. Results for other bleeding types are shown in Additional File 4.