Table 3 Factors associated in multivariate analysis with RFPN in the worldwide population (P3)
Low haptoglobin | Low ApoA1 | High ApoA1 | Low A2M | High A2M | |
|---|---|---|---|---|---|
Risk for FibroTest | False Positive | False Positive | False Negative | False Negative | False Positive |
Number of patients | 1,590 | 118 | 732 | 419 | 427 |
Range | 0.01-0.08 g/L | 0.10-0.41 g/L | 2.51-6.97 g/L | 0.10-0.80 g/L | 5.90-9.68 g/L |
Factor (n) | Odds Ratio (95% CI) P value 1 | ||||
Analytical factor | |||||
Last 3 years of test | 0.76 (0.68-0.84) P < 10-5 | NS | NS | NS | NS |
> 10,000 tests | 0.44 ((0.39-0.50) P < 10-5 | NS | 0.48 ((0.39-0.50) P < 10-5 | NS | NS |
Non analytical factor | |||||
Residency | |||||
Western Europe | NS | NS | NS | NS | NS |
North Africa | NS | NS | NS | NS | NS |
North America | 0.05 (0.01-0.20) P = 0.00005 | NS | NS | NS | NS |
Eastern Europe | NS | NS | NS | 22.44 (5.55-90.85) P < 10-4 | NS |
HIV center | 3.97 (2.88-5.48) P < 10-5 | NS | NS | NS | NS |
Age > 50 years | 0.63 (0.57-0.70) P < 10-4 | NS | 1.86 (1.60-1.86) P < 10-5 | NS | 1.56 (1.29-1.90) P = 10-4 |
Male gender | 1.30 (1.18-1.45) P < 10-4 | NS | 0.34 (0.29-0.40) P < 10-5 | 2.6 (2.07-3.28) P < 10-5 | NS |
Reference center | 5.35 (4.67-6.13) P < 10-5 | 2.61 (1.66-4.13) P = 0.00003 | 1.84 (1.39-2.45) P < 10-5 | 1.83 (1.36-2.47) P = 0.00008 | NS |