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Table 3 Factors associated in multivariate analysis with RFPN in the worldwide population (P3)

From: Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age

  Low haptoglobin Low ApoA1 High ApoA1 Low A2M High A2M
Risk for FibroTest False Positive False Positive False Negative False Negative False Positive
Number of patients 1,590 118 732 419 427
Range 0.01-0.08 g/L 0.10-0.41 g/L 2.51-6.97 g/L 0.10-0.80 g/L 5.90-9.68 g/L
Factor (n) Odds Ratio (95% CI) P value 1    
Analytical factor      
Last 3 years of test 0.76 (0.68-0.84) P < 10-5 NS NS NS NS
> 10,000 tests 0.44 ((0.39-0.50) P < 10-5 NS 0.48 ((0.39-0.50) P < 10-5 NS NS
Non analytical factor      
Residency      
   Western Europe NS NS NS NS NS
   North Africa NS NS NS NS NS
   North America 0.05 (0.01-0.20) P = 0.00005 NS NS NS NS
   Eastern Europe NS NS NS 22.44 (5.55-90.85) P < 10-4 NS
HIV center 3.97 (2.88-5.48) P < 10-5 NS NS NS NS
Age > 50 years 0.63 (0.57-0.70) P < 10-4 NS 1.86 (1.60-1.86) P < 10-5 NS 1.56 (1.29-1.90) P = 10-4
Male gender 1.30 (1.18-1.45) P < 10-4 NS 0.34 (0.29-0.40) P < 10-5 2.6 (2.07-3.28) P < 10-5 NS
Reference center 5.35 (4.67-6.13) P < 10-5 2.61 (1.66-4.13) P = 0.00003 1.84 (1.39-2.45) P < 10-5 1.83 (1.36-2.47) P = 0.00008 NS
  1. 1 Only odds ratio with P value lower or equal to 0.0001 were considered significant