Figure 10

Expression of TNF-α in UC patients (n = 49). mRNA results were determined by RT-PCR. TNF-α gene expression was not significantly different in UC patients with intestinal MAP detection and those without (p = 0.416) and did not differ between patients receiving an anti-inflammatory therapy (AIT) and those without AIT (p = 0.533). Further stratification into subgroups of patients receiving 5-amino salicylic acid (5-ASA) and its derivatives, corticosteroids or immunomodulators (azathioprine and infliximab) revealed no significant differences in TNF-α expression between patients treated with the respective substance and those not receiving the respective agent. Note, that some patients received more than one substance class and therefore appear in more than one subgroup.