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Table 2 Demographic and clinical parameters correlated with different degrees of SRF up-regulation on gastric ulcers

From: Weak up-regulation of serum response factor in gastric ulcers in patients with co-morbidities is associated with increased risk of recurrent bleeding

Up-regulation of SRF Strong
(n = 18)
Intermediate
(n = 83)
Weak
(n = 41)
P
value
Female: Male 7 : 11 29 : 54 22 : 19 0.13
Mean age (yr) 62.3 66.4 67.0 0.53
Ulcer characteristics (n)  
   SRH, Forrest classification Ia to IIc (%) 22.2 61.4 58.5 0.01
   Mean ulcer size (cm) 1.51 1.47 1.70 0.65
Endoscopic hemostatic therapy in patients with Forrest classification Ia to IIb SRH (%) 100 91.9 100 0.52
H. pylori infection (%) 61.1 62.7 68.3 0.80
NSAID user (%) 55.6 50.6 58.5 0.70
Comorbidity (%) 33.3 57.8 58.5 0.14
Mean Hb (g/dL) 10.2 10.0 9.6 0.71
Platelet (mm3) 300.4 244.7 247.3 0.24
Serum albumin <3 g/dL (%) 37.5 26.4 36.0 0.62
Serum Creatinine ≥ 1.5 mg/dL (%) 20.0 26.3 33.3 0.58
  1. Up-regulation of SRF indicated the distribution of net-positive increase of SRF intensity in ulcer tissues than in non-ulcer tissues of superficial epithelium, mononuclear cells of the lamina propria, and mucosal smooth muscle cells, respectively. SRF: serum response factor; SRH: stigmata of recent hemorrhage; H. pylori: Helicobacter pylori; NSAID: non-steroidal anti-inflammatory drugs; Hb: hemoglobin. One-way ANOVA and Pearson χ2 test were used as appropriate. Reference range: Hb level, 13.5-17 g/dL; platelet count; 138.1-353.4 × 103/cmm; serum albumin level, 3.5-5 g/dL; serum creatinine, 0.7-1.5 mg/dL.