K8 expression along the crypt axis. Figure 2Ai shows K8 staining reaching to the bottom of the crypt, but in some crypts it reached only the upper one third (Aii) and in others upper two third was stained with K8 (A-iii). The relative occurrence of each class of staining is show in Figure 2B. Only few percent of crypts were without staining (5.37% in MS group and 8.62% in CO group) but majority of the crypts scored K8 staining reached to the bottom in both MS and CO (51.72% in CO and 46.24% in MS). There was no significant difference in the mean scores in two groups (C).