Transcript levels of Toll-Like receptors 5, 8 and 9 correlate with inflammatory activity in Ulcerative Colitis

BMC Gastroenterology

Table 3 Transcript levels of TLRs and pro-inflammatory cytokines in colonic mucosa from UC patients and Controls

GENE mRNA	Control N = 36	UC Patients N = 51	UC Quiescent N = 21	UC Active N = 31	Control vs UC	Control vs UC Quiescent	Control vs UC Active	UC Quiescent vs Active
	Transcript Levels				P value
TLR1	0.75±0.50	1.12±1.63	1.33±2.51	0.98±0.53	0.26	0.64	0.13	0.11
TLR2	0.63±0.25	1.63±2.5	0.72±0.4	2.55±3.30	0.14	0.9	0.001	0.002
TLR3	0.54±0.25	0.75±0.5	0.87±0.60	0.63±0.39	0.6	0.18	0.7	0.27
TLR4	0.64±0.23	1.3±0.94	1.01±0.62	1.55±1.12	0.002	0.015	0.0001	0.04
TLR5	0.94±0.58	0.86±0.5	0.71±0.46	0.96±0.52	0.75	0.14	0.55	0.06*
TLR6	0.91±0.61	0.8±0.67	0.59±0.36	0.94±0.79	0.52	0.11	0.56	0.19
TLR7	0.71±0.45	0.62±0.79	0.77±1.21	0.52±0.27	0.86	0.14	0.13	0.82
TLR8	1.13±0.73	1.96±2.19	0.88±0.59	2.67±2.56	0.04	0.22	0.001	0.0005
TLR9	0.75±0.57	1.12±1.1	0.66±0.37	1.60±1.26	0.037	0.95	0.004	0.006
TOLLIP	0.79±0.21	0.84±0.28	0.85±0.32	0.83±0.26	0.41	0.69	0.82	0.86
TNF	0.96±1.28	0.84±0.79	0.4±0.37	1.24±0.86	0.96	0.01	0.023	< 0.001
IL6	1.8±3.5	8±19.5	1.6±3.2	11±23	0.039	0.8	< 0.001	< 0.001

Transcript levels are shown as means and standard deviations. P with significance are underlined and * for trend.

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