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Figure 1 | BMC Gastroenterology

Figure 1

From: Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model

Figure 1

Gastrointestinal permeability. Intestinal permeability was determined using lactulose and mannitol. After a fasting period of 12 hours GvHD-mice (n = 20), control animals (n = 18) and non irradiated B6D2F1 mice (n = 8) received 1 ml of the lactulose/mannitol solution by orogastral tube. One hour after feeding serum concentrations of lactulose (representative for paracellular permeability) and mannitol (representative for transcellular permeability) were determined using melibiose as internal standard as described. A) mean and SD of mannitol and lactulose serum concentrations normalized to melbiose. * indicates p-values < 0.05 and ** p-values < 0.01. B) Lactulose/mannitol quotient. * indicates p-value < 0.05.

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BMC Gastroenterology

ISSN: 1471-230X

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