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Table 4 Characteristics of included studies in the meta-analysis.

From: Narrow-band imaging does not improve detection of colorectal polyps when compared to conventional colonoscopy: a randomized controlled trial and meta-analysis of published studies

Study Methods Participants Interventions Primary Outcomes Risk of bias*
Adler 2009 Open-label, prospective, randomized, controlled, multicenter trial 1256 patients, mean age, 64.4 years (range 31-87 y) undergoing screening colonoscopy Wideangle colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal (6 endoscopists). Exera II system. Number of
adenomas/number of patients examined
Unclear
Adler 2008 Open-label, prospective, randomized, controlled trial 401 patients with a mean age of 59.4 years (SD 13.4) undergoing diagnostic colonoscopy Wideangle colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal (7 endoscopists). Exera II system. Adenoma detection rate Unclear
East 2009 (abstract) Open-label, prospective, randomized, controlled trial 214 high risk adenomas patients with a median age of 65 and 66 years in the NBI and conventional group respectively Examination with NBI or white light (WLE), with high definition (HDTV) colonoscopes (3 endoscopists). Lucera system. The number of patients with at least one adenoma detected. Unclear
Inoue 2008 Open-label, prospective, randomized, controlled trial 243 patients (NBI mean age, 61.1 SD 13.5; conventional mean age 62.9 SD 11.3) undergoing surveillance or diagnostic colonoscopy Colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal (6 endoscopists). Lucera system. Mean number of adenomas per patient Unclear
Kaltenbach 2008 Open-label, prospective, randomized, controlled trial 276 patients with a mean age of 64 (SD 10) years (range 31 to 89), undergoing screening, surveillance or diagnostic colonoscopy Wideangle colonoscopy using either conventional high-resolution imaging or NBI (6 endoscopists); back-to-back colonoscopy by the same endoscopist. Exera II system. Neoplasm miss rate. Low
Paggi 2009 Open-label, prospective, randomized, controlled trial 211 patients (from 50 to 69 years) with positive immunologic fecal occult blood tests Colonoscopy withdrawal in white light versus NBI (6 endoscopists). Exera II system. The detection
rate of adenoma
Unclear
Rex 2007 Open-label, prospective, randomized, controlled trial 434 patients aged 50 years or older undergoing screening or surveillance colonoscopy Colonoscopy withdrawal in white light versus NBI (only one endoscopist; high definition monitors were used). Exera II system. Number of adenomas Unclear
Sabbagh 2011 Open-label, prospective, randomized, controlled, multicenter trial 482 patients with a mean age of 58.3 (SD 12.9) undergoing screening, surveillance or diagnostic colonoscopy Wideangle colonoscopy using either conventional high-resolution imaging or NBI (3 endoscopists). Exera II system. Mean number of adenomas  
  1. *The judgment for each entry involves answering a question, with answers "Yes" indicating low risk of bias, "No" indicating high risk of bias, and "Unclear" indicating either lack of information or uncertainty over the potential for bias