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Table 1 Correlation between the protein expression of pGSK-3βTyr216 and clinicopathological factors for 281 human gastric caicinoma specimens.

From: Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer

 

Active GSK-3β

Positive (%)

Active GSK-3β

Negative (%)

Pvalue

Total (n = 281)

129 (46)

152 (54)

 

Age (y)

   

   0-39

21 (46)

25 (54)

0.881

   40-65

83 (47)

94 (53)

 

   66-99

25 (43)

33 (57)

 

Gender

   

   Male

94 (49)

98 (51)

0.157

   Female

35 (39)

54 (61)

 

Locus

   

   Antrum

63 (42)

86 (58)

0.230

   Body and Cardia

66 (50)

66 (50)

 

WHO classification

   

   WD

21 (78)

6 (22)

< 0.001*

   MD

42 (53)

37 (47)

 

   PD

44 (37)

74 (63)

 

Lauren's classification

   

   Intestinal

63 (59)

44 (41)

< 0.001*

   Diffuse

62 (37)

107 (63)

 

   Mixed

4 (80)

1 (20)

 

TNM stage

   

   I

53 (69)

24 (31)

< 0.001*

   II

60 (43)

80 (57)

 

   III

16 (27)

44 (73)

 

   IV

0 (0)

4 (100)

 

Lymphatic invasion

   

   Absent

104 (53)

93 (47)

< 0.001*

   Present

25 (30)

59 (70)

 

Lymph node metastasis

   

   Absent

63 (63)

37 (37)

< 0.001*

   Present

66 (36)

115 (64)

 

Distant metastasis

   

   Absent

124 (47)

141 (53)

0.304

   Present

5 (31)

11 (69)

 
  1. WD: well-differentiated adenocarcinoma; MD: moderately-differentiated adenocarcinoma; PD: poorly-differentiated adenocarcinoma.
  2. * Considered to be statistically significant (< 0.05).
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BMC Gastroenterology

ISSN: 1471-230X

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