Figure 2From: Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice Villus height (A) and crypt depth (B) after 7 days of treatment with either nelfinavir (NFV, 100 mg/kg), indinavir (IDV, 100 mg/kg), zidovudine (AZT, 50 mg/kg) and didanosine (DDI, 100 mg/kg) or PBS. For each animal, a total of 10 villi and 10 crypts were measured for each segment of duodenum, jejunum, and ileum with a micrometer. The results are expressed as mean Ā± SEM of six mice per group. *statistical significance (P < 0.05) compared to the PBS control group by ANOVA, Bonferroni's multiple test. (C) Illustrative pictures of the effects of CONTROL (PBS), NFV (100 mg/kg), DDI (100 mg/kg), IDV (100 mg/kg), AZT (50 mg/kg) on the intestinal jejunal tissue, showing decreased villi length caused by all antiretrovirals and increased crypt depth caused by AZT.Back to article page