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Table 2 Effects of melatonin on patients with GERD group II (n = 9)

From: The potential therapeutic effect of melatonin in gastro-esophageal reflux disease

  Pretreatment with melatonin 4 weeks Post treatment with melatonin 8 weeks Post treatment with melatonin
   Symptoms:    
1-Heart burn:    
Yes 7 3 (57.1%) 0 (100%)
Duration(months) 1.3 ± 0.4   
2-Epigastric pain:    
Yes 6 3 (50%) 1 (83%)
Duration(months) 1.4 ± 0.5   
   B)LES Study:    
1-LES pressure(mmHg) 10 ± 1.58 14.5 ± 1.58a 20.2 ± 1.56 ab
2-Residual pressure (mmHg) 0.012 ± 0.52 0.2 ± 0.016 0.32 ± 0.013a
3-Relaxation duration (seconds) 6.8 ± 0.12 5.9 ± 0.16 a 5.3 ± 0.12 a
4-Relaxation % 86 ± 0.87 90 ± 0.86 a 100 ± 0.00 ab
C) PH (at 5 cm above the LES): 2.3 ± 0.36 5.2 ± 0.5 a 6.7 ± 0.65 ab
D) BAO (mmol/h) 24.7 ± 0.5 20.1 ± 0.4 a 16.6 ± 0.6 ab
E) Serum Gastrin(pg/ml) 22.1 ± 3.2 27.2 ± 2.3 a 32.3 ± 2.1 ab
D) Melatonin level at day time (pg/ml): 18.2 ± 5.54 28.26 ± 2.26 a 34.5 ± 2.35 ab
  1. a: p < 0.05 relative to pretreatment with melatonin
  2. b: p < 0.05 relative to 4 weeks post treatment with melatonin