Figure 5

Effect of T cell-specific PPAR γ deletion on inflammatory gene expression. WT or CD4cre mice were treated with 2.5% dextran sodium sulfate (DSS) for 7 days, and microarray analyses was performed on colon samples. Differences in interleukin 6 (IL-6) (A), IL-1β (B), and suppressor of cytokine signaling 3 (SOCS-3) (C) were compared among groups and validated with real time PCR. Expressions of (IL-6 (D), vascular adhesion molecule 1 (VCAM-1) (E), intracellular adhesion molecule 1 (ICAM-1) (F), integrin alpha V (intgav) (G), and SOCS-3 (H) on days 0 and 7 were examined by real time PCR to validate microarray findings. Points with an asterisk are significantly different from the day 0 time point (P < 0.05). Points with a double asterisk also indicate a significant difference due to genotype at a given time point (P < 0.05).