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Table 2 Haplotypes in the UGT1A1 transcriptional regulatory region

From: Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome

type Number of allele gtPBREM Polymorphisms in the region between gtPBREM and TATA box TATA box
  JRSa
(100) e
JG7b
(8) e
NCc
(20) e
CGd
(22)e
-3275 -3152 -2951 -2743 -2737 2726 -2724AT[n] -2473 -1352 -1125 -997 -689 -364 A(TA)nTAA
      Haplotypes with A(TA)6TAA
I 68 0 11 0 T G A T T G 3 T A C G A C 6
II 19 0 4 0 G G A T T A >8 G C C A C C 6
III 0 0 1 0 T G A T T G 3 G C C A C C 6
IV 2 0 0 0 T G A T T G 3 T C C A A C 6
      Haplotypes with A(TA)7TAA
V 10 8 0 0 G A* G* C* C* A* 8* G* C* C G C* T* 7
VI 1 0 3 12 G A G C C A >8 G C C G C T 7
VII 0 0 1 5 G G G C T A >8 G C C G C T 7
VIII 0 0 0 4 G G G C C A >8 G C T G C T 7
IX 0 0 0 1 G A G C C A >8 G C T G C T 7
  1. Boldfaces indicate variations.
  2. aJRS, Japanese random subjects; bJG7, Japanese patients with Gilbert syndrome having homozygous A(TA)7TAA; cNC, normal Caucasians; dCG, Caucasian patients with Gilbert syndrome; eNumbers in parentheses indicate the number of total alleles in each group
  3. *Ten linked polymorphisms between gtPBREM and TATA box