Prognostic prediction across a gradient of total tumor volume in patients with hepatocellular carcinoma undergoing locoregional therapy

Table 2 Distribution of the number and size of tumor and total tumor volume

No. of tumors and patients, and total tumor volume (cm³)	Maximal tumor diameter (cm)			p
	<3	3-6	>6
One nodule
No. of patients	238	148	114
Total tumor volume	5 ± 4	44 ± 29	730 ± 692	<0.001^a
(median)	(4)	(34)	(524)
Two nodules
No. of patients	73	45	32
Total tumor volume	7 ± 5^d	53 ± 29	720 ± 746	<0.001^b
(median)	(6)	(51)	(372)
Three nodules
No. of patients	34	22	10
Total tumor volume	7 ± 5^e	45 ± 29	472 ± 429	<0.001^c
(median)	(6)	(33)	(278)
Four or more nodules
No. of patients	34	21	15
Total tumor volume	10 ± 6^f	59 ± 41	937 ± 719
(median)	(11)	(66)	(703)
p	<0.001	0.054	0.177

Kruskal-Wallis test with post-test: a, b and c: p values all <0.05 for pairwise comparison between the 3 groups; d vs e, d vs f and e vs f: p values all >0.05.

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