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Table 3 Relationships between the microsatellite genotypes and the clinicopathologic features of gastric cancers

From: The gene-reduction effect of chromosomal losses detected in gastric cancers

Characteristics   High-risk genotypes   Low-risk genotypes   Pvalue
  (%) LOH-H (%)* LOH-B (%)* Pvalue LOH-L (%)* MSI (%)* Pvalue  
No. of patient 145 50 15   65 15   
Age (year)     < 0.0001    0.038 0.710
   Mean 61 65 45   60 67   
   SD ± 12.5 ± 9.8 ± 12.7   ± 11.6 ± 9.8   
Sex     0.118    0.008 0.393
   Male 90 (62) 36 (72) 7 (47)   43 (66) 4 (27)   
   Female 55 (38) 14 (28) 8 (53)   22 (34) 11 (73)   
Tumor size     0.247    0.502 0.394
   Mean 5.34 5.3 6.34   5.0 5.6   
   SD ± 2.94 ± 2.62 ± 3.77   ± 3.10 ± 2.33   
Differentiation     0.052    0.094 0.033
   Well 11 (8) 3 (6)    8 (12)    
   Moderate 53 (36) 17 (34) 1 (7)   25 (39) 10 (67)   
   Poor 81 (56) 30 (60) 14 (93)   32 (49) 5 (33)   
Tumor location     < 0.0001    0.037 0.791
   Cardia 13 (9) 3 (6) 4 (27)   6 (9)    
   Body 50 (35) 12 (24) 10 (67)   26 (40) 2 (13)   
   Antrum 82 (56) 35 (70) 1 (6)   33 (51) 13 (87)   
Lauren classification     < 0.0001    0.016 < 0.0001
   Intestinal 58 (40) 19 (38) 0 (0)   35 (54) 4 (27)   
   Diffuse 32 (22) 9 (18) 15 (100)   8 (12) 0 (0)   
   Mixed 55 (38) 22 (44) 0 (0)   22 (34) 11 (73)   
Growth pattern     0.600    < 0.0001 < 0.0001
   Expanding 20 (14) 1 (2) 1 (7)   9 (14) 9 (60)   
   Infiltrative 70 (48) 32 (64) 10 (67)   28 (43)    
   Mixed 55 (38) 17 (34) 4 (26)   28 (43) 6 (40)   
Lymphatic invasion     1.000    0.771 0.006
   No 44 (30) 9 (18) 3 (20)   34 (52) 5 (33)   
   Yes 101 (70) 41 (82) 12 (80)   31 (48) 10 (67)   
Venous invasion     0.351    0.113 0.005
   No 112(77) 35 (70) 8 (53)   54(83) 15 (100)   
   Yes 33 (23) 15 (30) 7 (47)   11 (17)    
Tumor stage     0.757    0.763 < 0.0001
   Early 75 (52) 16 (32) 6 (40)   42 (65) 11 (73)   
   Advanced 70 (48) 34 (68) 9 (60)   23 (35) 4 (27)   
Recurrence     0.035    0.517 0.023
   Non-hematogenous 36 (62) 18 (36) 10 (67)   14 (22) 2 (13)   
   Hematogenous 22 (38) 19 (38) 2 (13)   3 (5)    
Vital status 130    1.000    1.000 < 0.0001
   Alive 80 (61) 14 (32) 4 (27)   52 (87) 10 (91)   
   Dead 50 (39) 30 (68) 11 (73)   8 (13) 1 (9)   
  1. P values less than 0.05 are indicated in boldface print.
  2. *The gastric cancers were categorized into high-level LOH (LOH-H), baseline-level LOH (LOH-B), low-level LOH (LOH-L) and microsatellite instability (MSI). The details are described in the material and methods section.