Table 3 Relationships between the microsatellite genotypes and the clinicopathologic features of gastric cancers
From: The gene-reduction effect of chromosomal losses detected in gastric cancers
Characteristics | Â | High-risk genotypes | Â | Low-risk genotypes | Â | Pvalue | ||
|---|---|---|---|---|---|---|---|---|
| Â | (%) | LOH-H (%)* | LOH-B (%)* | Pvalue | LOH-L (%)* | MSI (%)* | Pvalue | Â |
No. of patient | 145 | 50 | 15 | Â | 65 | 15 | Â | Â |
Age (year) | Â | Â | Â | < 0.0001 | Â | Â | 0.038 | 0.710 |
   Mean | 61 | 65 | 45 |  | 60 | 67 |  |  |
   SD | ± 12.5 | ± 9.8 | ± 12.7 |  | ± 11.6 | ± 9.8 |  |  |
Sex | Â | Â | Â | 0.118 | Â | Â | 0.008 | 0.393 |
   Male | 90 (62) | 36 (72) | 7 (47) |  | 43 (66) | 4 (27) |  |  |
   Female | 55 (38) | 14 (28) | 8 (53) |  | 22 (34) | 11 (73) |  |  |
Tumor size | Â | Â | Â | 0.247 | Â | Â | 0.502 | 0.394 |
   Mean | 5.34 | 5.3 | 6.34 |  | 5.0 | 5.6 |  |  |
   SD | ± 2.94 | ± 2.62 | ± 3.77 |  | ± 3.10 | ± 2.33 |  |  |
Differentiation | Â | Â | Â | 0.052 | Â | Â | 0.094 | 0.033 |
   Well | 11 (8) | 3 (6) |  |  | 8 (12) |  |  |  |
   Moderate | 53 (36) | 17 (34) | 1 (7) |  | 25 (39) | 10 (67) |  |  |
   Poor | 81 (56) | 30 (60) | 14 (93) |  | 32 (49) | 5 (33) |  |  |
Tumor location | Â | Â | Â | < 0.0001 | Â | Â | 0.037 | 0.791 |
   Cardia | 13 (9) | 3 (6) | 4 (27) |  | 6 (9) |  |  |  |
   Body | 50 (35) | 12 (24) | 10 (67) |  | 26 (40) | 2 (13) |  |  |
   Antrum | 82 (56) | 35 (70) | 1 (6) |  | 33 (51) | 13 (87) |  |  |
Lauren classification | Â | Â | Â | < 0.0001 | Â | Â | 0.016 | < 0.0001 |
   Intestinal | 58 (40) | 19 (38) | 0 (0) |  | 35 (54) | 4 (27) |  |  |
   Diffuse | 32 (22) | 9 (18) | 15 (100) |  | 8 (12) | 0 (0) |  |  |
   Mixed | 55 (38) | 22 (44) | 0 (0) |  | 22 (34) | 11 (73) |  |  |
Growth pattern | Â | Â | Â | 0.600 | Â | Â | < 0.0001 | < 0.0001 |
   Expanding | 20 (14) | 1 (2) | 1 (7) |  | 9 (14) | 9 (60) |  |  |
   Infiltrative | 70 (48) | 32 (64) | 10 (67) |  | 28 (43) |  |  |  |
   Mixed | 55 (38) | 17 (34) | 4 (26) |  | 28 (43) | 6 (40) |  |  |
Lymphatic invasion | Â | Â | Â | 1.000 | Â | Â | 0.771 | 0.006 |
   No | 44 (30) | 9 (18) | 3 (20) |  | 34 (52) | 5 (33) |  |  |
   Yes | 101 (70) | 41 (82) | 12 (80) |  | 31 (48) | 10 (67) |  |  |
Venous invasion | Â | Â | Â | 0.351 | Â | Â | 0.113 | 0.005 |
   No | 112(77) | 35 (70) | 8 (53) |  | 54(83) | 15 (100) |  |  |
   Yes | 33 (23) | 15 (30) | 7 (47) |  | 11 (17) |  |  |  |
Tumor stage | Â | Â | Â | 0.757 | Â | Â | 0.763 | < 0.0001 |
   Early | 75 (52) | 16 (32) | 6 (40) |  | 42 (65) | 11 (73) |  |  |
   Advanced | 70 (48) | 34 (68) | 9 (60) |  | 23 (35) | 4 (27) |  |  |
Recurrence | Â | Â | Â | 0.035 | Â | Â | 0.517 | 0.023 |
   Non-hematogenous | 36 (62) | 18 (36) | 10 (67) |  | 14 (22) | 2 (13) |  |  |
   Hematogenous | 22 (38) | 19 (38) | 2 (13) |  | 3 (5) |  |  |  |
Vital status | 130 | Â | Â | 1.000 | Â | Â | 1.000 | < 0.0001 |
   Alive | 80 (61) | 14 (32) | 4 (27) |  | 52 (87) | 10 (91) |  |  |
   Dead | 50 (39) | 30 (68) | 11 (73) |  | 8 (13) | 1 (9) |  |  |