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Table 1 Associations of GHRL and GHSR polymorphisms with colorectal cancer risk in the Czech population

From: Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

  Casesa Controlsa OR(95%)b P value P trend
GHRL      
rs26802      
G/G 286 278 1   
G/T 294 245 1.18(0.92-1.51) 0.18  
T/T 93 74 1.19(0.82-1.70) 0.25 0.16
rs27647      
C/C 279 198 1   
C/T 289 280 0.70(0.55-0.91) 0.008  
T/T 93 110 0.57(0.40-0.80) 0.002 0.001
rs35683      
A/A 204 147 1   
A/C 331 297 0.80(0.61-1.05) 0.11  
C/C 137 143 0.71(0.51-0.98) 0.04 0.02
rs4684677      
A/A 601 523 1   
A/C 78 74 0.91(0.64-1.30) 0.49  
C/C 4 3 1.63(0.35-7.68) 0.62 0.70
rs696217      
G/G 590 523 1   
G/T 84 71 1.09(0.77-1.55) 0.64  
T/T 4 6 0.60(0.16-2.18) 0.43 0.89
rs2075356      
C/C 559 498 1   
C/T 101 78 1.20(0.86-1.68) 0.63  
T/T 7 7 0.88(0.30-2.61) 0.36 0.28
rs35684      
A/A 257 248 1   
A/G 213 174 1.10(0.84-1.43) 0.46  
G/G 47 34 1.24(0.77-2.00) 0.36 0.29
GHSR      
rs2922126      
T/T 255 20 1   
A/T 269 274 0.81(0.62-1.05) 0.11  
A/A 74 39 1.48(0.95-2.30) 0.82 0.31
rs2944694      
A/A 564 477    
A/G 98 101 0.78(0.57-1.07) 0.14  
G/G 7 11 0.46(0.16-1.28 0.14 0.08
rs495225      
A/A 333 293 1   
A/G 232 220 0.88 (0.68-1.13) 0.33  
G/G 58 42 1.17(0.75-1.83) 0.47 0.77
rs572169      
C/C 329 305 1   
C/T 263 235 1.03(0.80-1.31) 0.80  
T/T 57 48 1.14(0.74-1.74) 0.55 0.62
  1. a Numbers may not add up to 100% of subjects due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to two additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.
  2. b OR: odds ratio; CI: confidence interval. Adjusted for age and gender. Results in bold are statistically significant (p < 0.05)