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Table 1 Metabolic pathways regulated by the considered genes, effect of polymorphisms on protein function and metabolic parameters.

From: Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

Gene Function Polymorphism Effect Previous association
PPARα Induces lipolysis Lys162Val
- Insulin resistance
Diabetes [29]
PPARγ2 Induces lipogenesis in adipose tissue Pro12Ala
- Insulin sensitivity
[32, 40]
  1. -: loss-of-function allele