Skip to main content

Advertisement

Table 1 Metabolic pathways regulated by the considered genes, effect of polymorphisms on protein function and metabolic parameters.

From: Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

Gene Function Polymorphism Effect Previous association
PPARα Induces lipolysis Lys162Val
(rs1800206)
- Insulin resistance
Dyslipidemia
Diabetes [29]
PPARγ2 Induces lipogenesis in adipose tissue Pro12Ala
(rs1801282)
- Insulin sensitivity
[32, 40]
  1. -: loss-of-function allele