Impact of severe postoperative complications on the prognosis of older patients with colorectal cancer: a two-center retrospective study

Table 4 Univariate and multivariate analyses for cancer-specific survival in older patients

Variables		n = 191	Univariate		Multivariate
Variables		n = 191	5-years CSS (%)	P-value ^d	HR	95% CI	P-value ^e
Age, years	≥ 85 < 85	61 130	82.2 84.0	0.638
Sex	Female Male	97 94	79.2 87.9	0.115
BMI, kg/m²	> 22 ≤ 22	87 104	87.4 80.1	0.318
ASA-PS	≥ 3 < 3	61 130	69.6 88.3	0.156
Location	Colon Rectum	136 55	83.7 83.8	0.939
Histopathological type^a	por/sig/muc tub/pap	22 169	73.6 84.8	0.220
T stage^b	T4 T1-3	31 160	57.2 88.8	< 0.001	4.12	1.73–9.83	0.001
N stage^b	N1-2 N0	69 122	73.7 89.5	0.002	3.25	1.25–8.40	0.014
Lymphatic invasion	Presence Absence	135 56	81.5 87.7	0.331
Venous invasion	Presence Absence	111 80	78.8 89.4	0.299
Severe postoperative complication^c	Presence Absence	14 177	61.1 85.3	0.007	4.00	1.27–12.6	0.017

a: According to the Japanese classification of colorectal carcinoma, 8th edition
b: According to the 7th edition of the UICC/TNM staging system
c: Grade 3 or higher according to the Clavien–Dindo classification
d: P values are from the log-rank test
e: P values are from Cox’s proportional hazard model
CSS Cancer-specific survival, HR Hazard ratio, CI Confidence interval, tub tubular adenocarcinoma, pap papillary adenocarcinoma, por poorly differentiated adenocarcinoma, sig signet-ring cell carcinoma, muc mucinous adenocarcinoma, ASA-PS American Society of Anesthesiologists Physical Status, BMI body mass index

ISSN: 1471-230X