Impact of severe postoperative complications on the prognosis of older patients with colorectal cancer: a two-center retrospective study

Table 3 Univariate and multivariate analyses for cancer-specific survival

Variables		n = 760	Univariate		Multivariate
Variables		n = 760	5-years CSS (%)	P-value ^d	HR	95% CI	P-value ^e
Age, years	≥ 80 < 80	191 569	82.5 90.3	0.047	1.65	0.95–2.87	0.070
Sex	Female Male	331 429	90.3 87.9	0.610
BMI, kg/m²	> 22 ≤ 22	389 371	90.0 87.6	0.444
ASA-PS	≥ 3 < 3	153 607	75.6 91.4	< 0.001	2.47	1.45–4.20	< 0.001
Location	Rectum Colon	251 509	85.1 90.8	0.025	2.10	1.26–3.50	0.004
Histopathological type^a	por/sig/muc tub/pap	62 698	79.4 89.7	0.019	1.65	0.82–3.33	0.156
T stage^b	T4 T1-3	138 622	74.5 92.0	< 0.001	3.19	1.83–5.55	< 0.001
N stage^b	N1-2 N0	284 476	79.5 94.6	< 0.001	2.99	1.67–5.35	< 0.001
Lymphatic invasion	Presence Absence	483 277	85.7 94.2	0.001	1.40	0.70–2.79	0.331
Venous invasion	Presence Absence	420 340	86.2 92.0	0.049	1.15	0.64–2.06	0.630
Severe postoperative complication^c	Presence Absence	56 704	82.3 89.4	0.069

a: According to the Japanese classification of colorectal carcinoma, 8th edition
b: According to the 7th edition of the UICC/TNM staging system
c: Grade 3 or higher according to the Clavien–Dindo classification
d: P values are from the log-rank test
e: P values are from Cox’s proportional hazard model
CSS Cancer-specific survival, HR Hazard ratio, CI Confidence interval, tub tubular adenocarcinoma, pap papillary adenocarcinoma, por poorly differentiated adenocarcinoma, sig signet-ring cell carcinoma, muc mucinous adenocarcinoma, ASA-PS American Society of Anesthesiologists Physical Status, BMI body mass index

ISSN: 1471-230X