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Table 1 The baseline patient characteristics and risk factors for hepatocellular carcinoma

From: Management of hepatocellular carcinoma, an important cause of death in Japanese autoimmune hepatitis patients

Characteristic

HCC+ (n = 12)

HCC- (n = 119)

Univariate analysis

Multivariate analysis

odds ratio

95%CI

p

odds ratio

95%CI

p

autoimmune hepatitis

10

77

2.73

0.68–18.28

0.17

   

elderly (≥ 65)

7

55

1.63

0.49–5.78

0.42

   

liver cirrhosis at diagnosis

11

25

41.36

7.52-774.05

< 0.05

39.93

5.72-845.26

< 0.0001

male

4

15

3.47

0.93–12.93

0.08

   

history of hepatitis virus

0

9

-

-

0.18

   

duration of autoimmune hepatitis (≥ 10years)

3

29

1.03

0.26–4.08

0.96

   

steroid use

8

64

1.72

0.49–6.18

0.39

   

fatty liver

4

33

1.30

0.37–4.62

0.69

   

alcohol

3

13

2.72

0.65–11.33

0.20

   

diabetes

5

14

5.36

1.50-19.19

< 0.05

4.58

0.60-42.77

0.14

history of blood transfusions

1

5

2.07

0.22–19.36

0.55

   

obesity

5

33

1.86

0.55–6.28

0.33

   

Fib-4 index (≥ 2.67)

10

74

3.04

0.64–14.51

0.12

   

ALT one year after diagnosis (≥ 31 IU/L)

7

27

5.44

1.40-26.75

< 0.05

3.12

0.56–21.46

0.21

IgG one year after diagnosis (≥ 1701 mg/dL)

4

21

2.33

0.64–8.47

0.21

   

Fib-4 index one year after diagnosis(2.67)

7

20

8.17

1.93–34.50

< 0.05

2.13

0.36–13.79

0.40

  1. Abbreviations: HCC, hepatocellular carcinoma; CI, Confidence Intervals; ALT, alanine transaminase; IgG, immunoglobulin G