Table 1 Maximum tensile strength including frequencies of intra-anastomotic rupture, observational data regarding the test animals, macroscopic and histological findings divided into the interventional group and the control group. All results are reported as mean (± standard deviation, SD) unless stated otherwise
Parameters | PCL scaffold anastomosis | Control anastomosis | P-value for difference |
|---|---|---|---|
Number of test animals included | 9 | 11 | |
Maximum Tensile Strength (MATS) (Newton) | |||
MATS-1 MATS-2 | 18.43 (± 8.31) 18.86 (± 7.81) | 17.78 (± 3.67) 21.73 (± 8.48) | 0.817 0.446 |
Intra-anastomotic rupture (number) | 0 | 2 | 0.479 |
Weight (kg) | |||
Preoperative Postoperative day 5 Weight gain | 20.45 (± 1.04) 23.14 (± 1.42) 2.84 (± 0.6) | 19.87 (± 1.53) 22.05 (± 1.40) 2.17 (± 0.41) | 0.315 0.099 0.009 |
Adhesion score (0–1) | 0.67 (± 0.5) | 0.55 (± 0.52) | 0.828 |
Histological parameters by Verhofstad score (0–3) | |||
Necrosis Polymorphonuclear cells Lymphocytes Macrophages Oedema Mucosal epithelium repair Submucosal-muscular layer repair Total Verhofstad score Collagen, mean % | 0.56 (± 0.53) 2 (± 0.71) 0.67 (± 0.5) 0 1.56 (± 0.53) 3 (± 0) 1.56 (± 0.53) 9.3 (± 1.73) 36.1 (± 12.44) | 0.4 (± 0.51) 1.7 (± 0.48) 0.5 (± 0.53) 0 0.9 (± 0.74) 2.6 (± 0.52) 0.91 (± 0.83) 6.9 (± 2.23) 44.1 (± 21.43) | 0.509 0.316 0.475 1.000 0.050 0.038 0.073 0.025 0.337 |