Table 3 Univariate and multivariate analysis of recurrence-free survival (RFS) in Gastric cancer (GC) patients underwent ESD/ gastrectomy in training cohort

P

HR

95% confidence interval

P

HR

95% confidence interval

Gender

male/female

0.176

1.129

0.940–1.357

Age

> 60 y/≤60 y

0.062

1.201

0.989–1.458

ASA

II/I

0.482

1.069

0.848–1.345

ECOG PS

1/0

0.347

0.892

0.692–1.147

Family history of gastric cancer

Yes/No

0.079

1.256

0.971–1.623

Tumor size

> 2.0 cm/≤2.0 cm

0.019

1.395

1.063–1.832

0.091

1.241

0.927–1.663

Differentiation

Poorly/ high + Moderately

0.029

1.342

1.032–1.746

0.037

1.286

1.017–1.624

Vascular invasion

Yes/No

< 0.001

2.014

1.548–2.616

< 0.001

1.852

1.381–2.454

P53

Yes/No

0.006

1.546

1.133–2.114

0.023

1.389

1.047–1.844

Ki-67

≥ 50%/<50%

0.301

1.153

0.896–1.484

Tumor infiltration

Submucosa/ Mucosa

0.018

1.405

1.065–1.856

0.052

1.224

0.999–1.501

MSI status

MSI-high/ (MSS/MSI-low)

0.485

1.114

0.844–1.472

Treatment method

ESD/ gastrectomy

0.102

1.200

0.973–1.479