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Fig. 5 | BMC Gastroenterology

Fig. 5

From: Nuclear respiratory factor 1 regulates super enhancer-controlled SPIDR to protect hepatocellular carcinoma cells from oxidative stress

Fig. 5

Clinical feature analysis of NRF1 and SPIDR expression. (A-B), NRF1 (A) and SPIDR (B) expression in HCC and normal liver (NL) tissues was analyzed based on the TCGA-LIHC dataset. NL, n = 50. HCC, n = 371. **P < 0.01, ****P < 0.0001. (C-D), NRF1 (C) and SPIDR (D) expression in different HCC grades was analyzed based on the TCGA-LIHC dataset. G1, n = 55. G2, n = 177. G3, n = 122. G4, n = 12. *P < 0.05, ***P < 0.001. (E-F), qRT-PCR was performed to detect the relative mRNA expression of NRF1 (E) and SPIDR (F) in L02, HepG2 and Hep3B cells. **P < 0.01. (G), Western blotting was used to detect the protein levels of NRF1 and SPIDR in L02, HepG2 and Hep3B cells. Data for A-D were shown as median ± SD. Data for E-F were shown as mean ± SD of three independent experiments.

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BMC Gastroenterology

ISSN: 1471-230X

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