Table 4 Univariate analysis of the correlation between baseline lymphocyte subsets and PFS

Age

0.109

0.741

 <65

3.30(3.15–3.45)

 ≥ 65

3.70(3.30–4.10)

Gender

3.957

0.047

 Female

3.30(2.99–3.61)

 Male

3.40(3.15–3.65)

BMI

0.000

0.997

 BMI<18.5kg/m2

3.30(3.09–3.53)

 BMI ≥ 18.5kg/m2

3.50(3.24–3.76)

Smoking history

1.362

0.243

 No

3.30(3.08–3.52)

 Yes

3.70(3.20–4.20)

Drinking history

0.611

0.435

 No

3.30(3.11–3.49)

 Yes

3.70(2.78–4.63)

Extensive metastasis

4.679

0.031

 No

3.70(3.18–4.22)

 Yes

3.30(3.15–3.45)

PD-L1 expression

9.787

0.002

 CPS<5

3.30(2.65–3.75)

 CPS ≥ 5

3.50(3.19–3.81)

Mismatch repair status

9.068

0.003

 pMMR

3.30(3.23–3.57)

 dMMR

11.00(0.00-22.92)

CD4 + T

4.545

0.033

 Low proportion group (<35.30%)

3.20(2.92–3.48)

 High proportion group(≥35.30%)

3.70(3.39–4.01)

CD8 + T

2.689

0.101

 Low proportion group (<30.90%)

3.70(3.22–4.18)

 High proportion group(≥30.90%)

3.30(3.11–3.49)

CD4+/CD8+

5.152

0.023

 Low ratio group (<1.21)

3.30(3.11–3.49)

 High ratio group (≥1.21)

3.50(2.93–4.07)

NK

7.383

0.007

 Low proportion group (<20.00%)

3.10(2.83–3.38)

 High proportion group(≥20.00%)

4.00(3.63–4.37)

Tregs

4.058

0.044

 Low proportion group (<6.20%)

3.20(3.05–3.35)

 High proportion group(≥6.20%)

3.70(3.35–4.05)

B

0.762

0.383

 Low proportion group (<5.30%)

3.30(3.07–3.53)

 High proportion group(≥5.30%)

3.50(3.20–3.80)