Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site

BMC Gastroenterology

Table 2 Adjusted odds ratios (OR) and 95% confidence intervals (CIs) for the association between each symptom and rectal anatomic site among patients diagnosed with colorectal cancer (N = 626)

Symptom	N (%)	Minimally Adjusted OR (95% CI)^ac	Adjusted OR (95% CI)^bc
Blood in Stool	250 (39.94)	4.08 (2.87, 5.80)^*	4.37 (3.02, 6.33)^*
Changes to Stool	193 (30.83)	1.91 (1.33, 2.73)^*	1.78 (1.21, 2.60)^*
Abdominal Pain	175 (27.96)	0.35 (0.23, 0.53)^*	0.30 (0.19, 0.47)^*
Anemia	70 (11.18)	0.44 (0.24, 0.81)^*	0.40 (0.21, 0.75)^*
Other Symptoms	114 (18.21)	0.41 (0.25, 0.66)^*	0.33 (0.19, 0.55)^*
Asymptomatic	178 (28.43)	0.68 (0.46, 1.00)	0.68 (0.44, 1.04)

^*Statistically significant (p-value < 0.05)
^aAdjusted for age at diagnosis (years)
^bAdjusted for age at diagnosis (years), sex (male, female), diabetes (yes, no), BMI (kg/m²), cancer stage (localized, regional, distant), race/ethnicity (white, people of color)
^cMost results remain statistically significant after a conservative Bonferroni correction for multiple comparisons

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